Denitrification

Nitric oxide is an intermediate of the bacterial respiratory pathway called denitrification.    We have a long standing interest in the model denitrifier Paracoccus denitrificans, with a particular focus on the regulation of expression of genes involved in denitrification.  The genome of this organism was sequenced at the DoE Joint Genome Institute.

Fig. 1.  Regulation of denitrification genes in P. denitrificans.  Signals (especially oxygen and nitric oxide concentrations) are monitored by regulatory proteins which control the transcription of the genes encoding the four respiratory complexes of the denitrification pathway.

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